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Class Notes for Microbiology & Immunology at McGill University

MIMM 214 Lecture Notes - Lecture 22: Ionomycin, Co-Stimulation, Cd28

LECTURE 21 TCR Signalling - How does TCR binding initiates signalling? Monday February 24 2014h - Heterodimer with help of CD3 and ITAMs etc. - Action shifted to transmembrane adaptors i.e. LAT T-Cell Activation - Second m...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 23: Cytotoxic T Cell, Adaptive Immune System, Lymph Node

Effector T-cells: Some General Features LECTURE 23 - Effector T-cells express higher levels of LFA-1 and CD2 - Effector T-cells down-regulate S1P1 expression temporarily = Friday February 28 2014 stay in lymph node to prol...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 19: Mhc Restriction, Clonal Selection, Lymphocyte

find more resources at oneclass.com Key Cellular Concepts - Two Signal Mo...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 20: Mhc Restriction, Skin Grafting, Cytokine Storm

Sepsis CASE 2 - Composition Monday February 17 2014h - Performance - Injury: ?S.aureus, S.pyogenes MHC Restriction is to the MHC of the CORTICAL EPITHELIAL - Sepsis and death CELLS (radio-resistant cells) - Performance sty...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 17: Somatic Hypermutation, Immunoglobulin Class Switching, Alternative Splicing

- Combinatorial joining LECTURE 17 - Junctional diversity Wednesday February 12 2014th - Imprecise Joining - P-additions - N-additions Generation of Antigen Receptor Diversity in T-cells - paring or TCRs TCR Diversificatio...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 11: Mhc Class I, Calnexin, Antigen

LECTURE 10 th Wednesday January 29 2014 Adaptive Immunity: Antigen Processing and Presentation MHC Class I Presentation Pathway - MHC Class I present endogenous peptides - Cell loads the MHC molecule as it is made in the E...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 10: Antigen-Presenting Cell, Mhc Class Ii, Mhc Class I

What is the MHC? LECTURE 9 - Major Histocompatibility Complex = Cluster of genes that code for molecules involved in Ag presentation to T-cells Monday January 27 2014th - In humans, it is known as the HLA complex (Human Le...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 12: Immunological Synapse, Disulfide, Thymus

LECTURE 11 Friday January 31 2014 Adaptive Immunity: T-cells T-cells - Type of lymphocytes - Arising in the thymus from bone-marrow progenitors - Key role in adaptive immunity - Identified by the expression of T-cell recep...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 9: Rubella Virus, Measles, Epithelium

CASE STUDY 1 th Friday January 24 2014 Rubella - German Measles Clinical Case - 23 yr old female on third month of pregnancy - Develops rash fever and swollen glands all over the body - Swollen lymph nodes - Rash disappear...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 7: Innate Immune System, Chemotaxis, Sepsis

Systemic Effects of Pro-Inflammatory Cytokines LECTURE 7 - Systemic means all over the body (no way to stop it) Monday January 20 2014h 2 Ways C Activation Contributes to Inflammation - 1) All 3 pathways of Complement Acti...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 5: Irak1, Rig-I, Myd88

Bacteria Sensing and NOD Signalling Cascade - NOD proteins are PRRs that are intracellular and reside in the LECTURE 5 cytoplasm in an inactive form - Will recognize peptidoglycan and acts as a Gram+ pump Wednesday January...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 214 Lecture Notes - Lecture 6: Phagocytosis, Phagosome, Microorganism

Microbicidal Respiratory Burst LECTURE 6 Friday January 17 2014 Phagocytosis Turns on Phagocytes - Microbicidal mechanism climax called the respiratory burst - All together leading to the the killing of the microbe - Phago...

Microbiology & Immunology
MIMM 214
Joaquin Madrenas
MIMM 211 Lecture Notes - Lecture 13: Dna Polymerase Iii Holoenzyme, Dna Mismatch Repair, Dna Repair
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find more resources at oneclass.com MIMM 211 Biology of Microorganisms (10/05/18) Lecture 13 Mismatch Repair These two enzymes follow the replication fork on t...

Microbiology & Immunology
MIMM 211
Benoit Cousineau
MIMM 211 Lecture Notes - Lecture 14: Start Codon, Transfer Rna, Genetic Code
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find more resources at oneclass.com MIMM 211 Biology of Microorganisms (10/10/18) Lecture 14 **announcements about midterm exam Mon Oct 22, 9:35-10:25am A to K in Maass 112 (our regular room) 40...

Microbiology & Immunology
MIMM 211
Benoit Cousineau
MIMM 211 Lecture Notes - Lecture 5: Diplococcus, Spirillum, Bacilli
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find more resources at oneclass.com MIMM 211 Biology of Microorganisms (09/14/18) Lecture 5 Major differences between pro and eukaryotes (continued) - Shape and arrangement of cells o Spherical or elli...

Microbiology & Immunology
MIMM 211
Benoit Cousineau

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