MIMM 211 Lecture Notes - Lecture 20: Opportunistic Infection, Antimicrobial Resistance, Immunosuppressive Drug

• School: McGill University
• Department: Microbiology & Immunology
• Course: MIMM 211
• Professor: Benoit Cousineau

Document Summary

Outline: why study bacterial pathogenesis, define bac pathogens, how they relate to infection, disease, host status influence on bacterial disease, overview of bacterial infection mechanism. Why study bacterial pathogenesis: bacterial pathogens cause a wide range of diseases, major cause of death worldwide, especially in vulnerable popls: children, low income countries, new diseases always emerging (epidemiology, ex. Not all host/bacteria interactions lead to disease: need to consider factors at play: bacteria virulence and amount, host defenses and degree of resistance (ex. microbiome colonization resistance) Host status impact susceptibility to a pathogen: host genetic defect in immunity, immunocompromised, ex. Bcg: bacillus calmette-guerin (cid:1) attenuated strain of mycobacteria, used as tb vaccine (cid:1) (cid:1) sometimes, a vaccine will actually infect someone who has a genetic defect in. Individuals may get infected with mycobacteria due to vaccine! some aspect of innate immunity: ex. Pseudomonas aeruginosa, opportunistic pathogen (cid:1) found ubiquitously in soil, water, can colonize skin/git (cid:1)