MIMM 211 Lecture Notes - Lecture 27: Stanley Falkow, Shigatoxigenic And Verotoxigenic Escherichia Coli, Listeria
13 Dec 2018
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Bacterial virulence factors: definitions, acquisition, examples. Two examples of bacterial pathogens: enterohemorrhagic e. coli, an extracell diarrhoeal pathogen, salmonella typhimurium, an intracell diarrhoeal pathogen. **prof shows us a clip of a macrophage chasing down a bacterium and engulfing it won"t be on the exam. Why bacterial factors lead to the development of disease. How to define bacterial virulence factors: molecular koch"s postulates. Stanley falkow, 1988: put together a framework to help us define what bacterial virulence factors are, the gene encoding present in strains of bacteria that cause the disease. Colonise or invade the host and/or: cause disease and/or, evade host defenses. Virulence-associated secretion systems: translocated effector proteins. 3 phages: coli can be harmless, in fact, there is a part of our intestine that is colonised by it. It can also be pathogenic there are a number of different strains that have acquired virulence factors through horizontal gene transfer giving them the ability to cause different diseases.
