MIMM 211 Lecture Notes - Lecture 15: Research In Computational Molecular Biology, Bacterial Conjugation, Tata Xover

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Bacterial plasmids and genetic exchange: we will see, general principles, bacterial recbom (genetic variability, bacterial plasmids, bacterial horizontal gene transfer, conjugation, transformation and transduction. Recombination rearrangement of nucleic acids to produce a new nt sequence. If they are more similar to one another, they will have a greater chance of recomb. Homologous recomb recomb between two similar (homologous) sequences. Crossing over is the actual process of exchanging homologous pieces of dna. Horizontal gene transfer transfer of genes or dna pieces from 1 organism to the other (between cells) Non-reciprocal recomb: only one piece of dna is incorporated into another piece, transfer is one way. Replicative recomb (mobile genetic elements: we will see conjugative plasmids that use this method to get inserted into genomes. 2 pieces of dna are closely related but don"t have the exact same sequence: dsdna break generated through damage or specific enzymes, helicases or nucleases recognise this ds break.

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