MIMM 214 Lecture Notes - Lecture 5: Fragment Crystallizable Region, Anaphylaxis, Hydrolysis
15 Mar 2017
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On exam may have a figure (say, of a process), and a question would be asked about the figure. Group of soluble proteins; mostly proteases in blood/body fluids (break down other proteins! ); these proteins are named c plus a number, some called factor plus a letter like factor b. Opsonization: coating the surface of pathogen, making it more susceptible to phagocytosis. Phagocytosis happens by the cell membrane surrounding the pathogen, eventually forming an intracellular vesicle called phagosome, and digesting the engulfed material. C5b is larger than c5a; b is a bigger fragment than a by convention; fragments result from proteolytic cleavage. Prrs (circulating in blood) recognize pathogens and bind to them. C1q either binds pathogen directly, or bind antibodies at fc region. C3 convertase converts c3 into c3a and c3b; very short-lived. Complement reacts to extracellular pathogens; happens in the blood. Intracellular pathogens do not get broken down by complement; they go through other mechanisms.
