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MIMM 214 Lecture Notes - Lecture 12: Thymus, Natural Killer Cell, Macrophage

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orangefrog35
15 Mar 2017
School
McGill University
Department
Microbiology & Immunology
Course
MIMM 214
Professor
Claire Trottier

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Document Summary

Recall: both mhc i & ii have immunoglobulin-like domains. Area with most variability is in the moose knuckles, while the conserved region in facing the cell membrane. Both mhc i & ii have a transmembrane portion. For both, the peptide is very tighly bound within cleft. Mhc i binds very short peptides: only bind 8-10 aa peptides in length. This signifies a significant amt of processing was done to chop to peptide into tiny pieces. Mhc ii binds peptides of various lengths: no length constriction. The bottom portion has 3 alpha and 1 beta: mhc i. So the t-cell interacting with it must be cd8+ Tcr is binding to both the peptide and the mhc i; interwoven together, all interacting with each other. T-cell receptor (tcr) is very specific for the entire peptide-mhc complex. This is different from an antibody, which does not need to recognize the. Mhc, but only need to recognize the antigen alone (specific to antigen alone)

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Related Questions

Immunology worksheet help?

1. In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon?
A. TAP
B. Ii
C. TCR
D. CLIP
E. RAG
2. Your chances of having the same MHC haplotype as your siblingare:
A. 1:2.
B. 1:4.
C. 1:16.
D. 1:8.
E. 1:1.
3. Which of the following is the BEST example of self-MHCrestriction of T cells?
A. A T-cell clone is deleted when it binds too tightly to selfMHC.
B. A T-cell clone responds more vigorously to a self-peptide thana foreign peptide.
C. A T-cell clone recognizes foreign MHC.
D. A T-cell clone only recognizes foreign peptides when presentedby self MHC.
E. All of the above
4. MHC molecules:
A. are conserved between individuals.
B. bind repeating patterns found on pathogens.
C. are recognized by T cells.
D. are membrane-bound molecules found exclusively on T cells.
E. are secreted by T cells and bind and neutralize antigen in theserum.
5. Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this?
A. They would compensate for low diversity in the MHC with highdiversity in the TCR.
B. They would compensate for low diversity in the MHC with highdiversity in the BCR.
C. They would rely only on innate immune responses.
D. They would be at higher risk of infection.
E. All of the above
6. How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress?
A. Six
B. Two
C. Three
D. One
E. None. Only APC express class I.
7. MHC polymorphisms tend to cluster:
A. in the peptide-binding groove.
B. in the transmembrane domain.
C. in the coreceptor contact residues.
D. in the framework region.
E. All of the above
8. A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to:
A. cells with no class II MHC.
B. a deficiency in CD8+ T cells.
C. cells with class II MHC only bound with CLIP.
D. cells with class II MHC bound with a variety ofself-antigens.
E. cells with no DO.
9. The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean?
A. This region is regulated by many different mechanisms.
B. Sequence variability is low in this region.
C. There are many introns in this region.
D. There are many different alleles of these genes.
E. It has the most different genes.
10. Which of the following is an example ofcross-presentation?
A. An exogenous peptide being presented on MHC class II
B. A B-cell antigen being presented to a T cell
C. An endogenous peptide being presented on MHC class I
D. An endogenous peptide being presented on MHC class II
E. An exogenous peptide being presented on MHC class I