MIMM 214 Lecture Notes - Lecture 14: Inbreeding, Lymph Node, Chromosome
15 Mar 2017
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Cd4+ t-cell (in blue) plays important role in allowing this cross-presentation to happen -- So that both cd4+ and cd8+ are activated, for a stronger response. Some pathogens will enter vesicles and survive; you need cd4+ help. You need cd4+"s cytokines to provide help for cd8+, at. You need cd4+"s cytokines to provide help for cd8+, at some stage of that response. exception in terms of being an indirect pathway; but cd4+ is needed to help activate cd8+ If antigen is presented on foreign mhc -- you don"t get recognition (like middle picture) Only recognition if:: self mhc + correct antigen. Allorecognition happens where you shouldn"t get recognition; recognition happens even though there"s. Tcr is inappropriately activated when it encounters non-self mhc. Transplanted organs: the only context in which a person would be exposed to non-self mhc. Can activate a broad range of t-cells that are specific for a wide range of antigens.
