MIMM 214 Lecture Notes - Lecture 16: Pd-L1, List Of Breaking Bad And Better Call Saul Characters, Il-2 Receptor
15 Mar 2017
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Cd80/cd86, or b7. 1/b7. 2, are expressed on the apc. There are two kinds of ligands on apc: cd80/cd86 (a. k. a. Instead of lck we have pi3k here as the first kinase phosphorylating the t-cell transmembrane protein, Here we have sh3 domain recruiting another kinase, instead of sh2 in signal one. If a t-cell ever encounters a fixed apc (no. Cd80/cd86, i. e. no costimulatory ligands), only receiving signal 1, this would activate the anergic genes in that t-cell. The t-cell thus becomes anergic; from now on it"d never respond to any stimulation. An anergic t-cell, encountering a normal apc, would not respond. Experimental context: when you block the cd28, even though you have normal apc, you still activate the anergic genes. This is why signal 2 is essential for survival. How/why/when: as apc intakes antigen, as its prr detects pamp on the antigen, one of the things that happens is expression of costimulatory molecules.
