MIMM 214 Lecture Notes - Lecture 25: Germinal Center, Chemokine Receptor, Complement Receptor
17 Apr 2017
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B cell activation - primary focus & germinal center. Signal 1 & signal 2 for b cells. Signal 1: ag binding to bcr (and lesser requirement for complement binding to complement receptor of b cell, this leads to signaling. Signal 2: pmhc on b cell must bind tcr on t cell, cd40 on b cell must bind cd40l on t cell, this leads to signaling. B cell activation outcomes: b cell encounters ag on scs macrophage or free-floating ag (in b cell zone, bcr:ag is internalized and processed. Increased expression of chemokine receptor --> targets b cell to t-b border. This is where b cell receives signal 2 and becomes activated: activated b cell has two choices, form primary focus in subcapsular region, migrate to follicle to form. B cell activation, proliferation & differentiation: b cell zone - b cells receive signal 1. Option 1: form primary focus: option 2: go to follicle and form germinal center.
