MIMM 214 Lecture Notes - Lecture 24: Mhc Class Ii, Antigen, Somatic Hypermutation
7 Jun 2018
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Lecture 25 – March 8, 2017
Clarifications
- Many different naïve T cells will be activated during an infection, each may recognize a different
pMHC
Signal 1 and signal 2 for B cells
- Signal 1
o Ag binding to BCR (and lesser requirement for complement binding to complement
receptor on B cell)
▪ Can see Ag in natural form
o This leads to signalling
- Signal 2
o pMHC on B cell must bind TCR on T cell
o CD40 on B cell binds CD40L on T cell
o This leads to signaling
Location
Where do all these interactions happen?
- B cell activation, differentiation and proliferation all occur in lymph nodes
- But each step occurs in different part of lymph node
- B cells migrate to different parts of lymph node during different stages
-
Subcapsular Sinus
- Where SCS macrophages are located and where they encounter Ag
T cell zone
- Where T cells get activated by interacting with DCs
B cell zone
- Where B cells encounter Ag and undergo later stages of proliferation and differentiation,
including in B cell follicles aka germinal centres
o Can detect free Ag or SCS macrophage with Ag on it
find more resources at oneclass.com
find more resources at oneclass.com
