MIMM 214 Lecture Notes - Lecture 23: Phosphorylation, Mhc Class Ii, Cd154

30 views4 pages

tealduck852

7 Jun 2018

School

McGill University

Department

Microbiology & Immunology

Course

MIMM 214

Professor

Claire Trottier

For unlimited access to Class Notes, a Class+ subscription is required.

Lecture 24 – March 6, 2017

Question

- Answer: C

- 1=iv; 2=iii; 3=ii; 4=i

Back to TFH Cells

- Secrete IL-21 and cytokines typical of type 1 (IFNgamma), type 2 (IL-4) or type 3 (IL-17)

responses

- Signal will activate to produce specific types of antibodies

- Tfh cells interact directly with B cells

- In response to all types of pathogens

B cells

- Lymphocyte

- Arise in bone marrow

- Key role in adaptive immunity

o Antigen specific

o Clonotypic

o Progenitors of antibody producing plasma cells

- Identified by expression of B cell receptor complexes on the cell surface = membrane bound Ig

Clonal selection and expansion

- Process of clonal selection

- Activated B cells undergo proliferation and differentiation

- One outcome: plasma cell that secreted antibodies

Signal 1: BCR binds antigen

B cells enter lymph node

- Naïve B cells circulating in the periphery pass through the lymph nodes and spleen regularly

- Enter lymph node through HEV

o If B cell does not encounter antigen

▪ Leaves via efferent lymphatics

▪ If doesn’t encounter Ag after a few months, dies via apoptosis

o If B cell does encounter antigen

▪ Provides a survival signal (Signal 1)

How does the antigen end up in the lymph node?

- Antigens from pathogens arrive in lymph node via afferent lymphatics

- This includes Ag that has been opsonized via complement pathway

- Ag may be transported via activated conventional DCs → transferred to follicular DCs in lymph

node

find more resources at oneclass.com

Unlock document

This preview shows page 1 of the document.
Unlock all 4 pages and 3 million more documents.

Already have an account? Log in

Document Summary

Secrete il-21 and cytokines typical of type 1 (ifngamma), type 2 (il-4) or type 3 (il-17) responses. Signal will activate to produce specific types of antibodies. Key role in adaptive immunity: antigen specific, clonotypic, progenitors of antibody producing plasma cells. Identified by expression of b cell receptor complexes on the cell surface = membrane bound ig. Activated b cells undergo proliferation and differentiation. One outcome: plasma cell that secreted antibodies. Na ve b cells circulating in the periphery pass through the lymph nodes and spleen regularly. If doesn"t encounter ag after a few months, dies via apoptosis. If b cell does encounter antigen: provides a survival signal (signal 1) Antigens from pathogens arrive in lymph node via afferent lymphatics. This includes ag that has been opsonized via complement pathway. Ag may be transported via activated conventional dcs transferred to follicular dcs in lymph node. B cells encounter antigen in the lymph node.

Related Questions

How did inoculation with cowpox generate immunological memory and provide protection against smallpox? Did cross-reactivity play a role?

How did Pasteurâs work with attenuated (weakened) bacteria further our understanding of the role vaccination can play?

What are the three characteristics that define an adaptive immune response? Briefly define each of the characteristics.

Define primary versus secondary immune response.

Whatâs the difference between totipotent, pluripotent, multipotent and oligopotent when evaluating cell differentiation capacity?

What is hematopoiesis?

What cell types are derived from myeloid versus lymphoid progenitor cells? Describe the function of each WBC type.

What is clonal selection?

What role do antibodies play with regard to antigen recognition and immune defense that is different from what Tcrs provide?

As described in class generally understand the outcome of B cell, Th cell, and Tc cell activation. Understand that these cells can differentiate into effector (plasma cells, cytokine producing Th cells and CTLs) or memory cells.

Understand how granzymes and perforins play a role in apoptosis.

Which types of cells typically express MHC Class II? Do these cell types also express MHC Class I, and if so why?

With regard to Tc and Th cells, what kinds of peptide antigens (think about exogenously versus endogenously derived antigens) are recognized?

Be able to show cooperation between Tc, Th and B cell responses (refer to class notes).

What is the overall role of MHC Class I and II?

What is ADCC and what cell types are involved?

Understand and be able to provide examples highlighting the cooperation between innate and adaptive immunity. Note: ADCC and dendritic cell and macrophage interactions with Th cells illustrate examples of innate/adaptive cooperation.

What are the primary lymphoid organs? What role do they play?

What role does the lymphatic circulatory system play in immune defense?

Whatâs the difference between plasma, ISF, and lymph?

Whatâs the difference between afferent and efferent lymphatic vessels?

How is lymph ultimately delivered back to blood?

Define extravasation. Why is this important?

What are HEVs and what role do they play?

What are the secondary lymphoid tissues/organs?

What role do lymph nodes play?

What role does the spleen play?

What is Leukocyte Adhesion Deficiency?

Whatâs MALT and its role?

What is the inflammatory response and what are characteristics associated with inflammation?

What role does histamine play in the inflammatory response?

limereindeer400

1. during inflamation fluid will passively diffuse out of blod vessels into the nearby infected tissue. This implies all of the following EXCEPT

a.the osmolarity of the fluid surrounding infected tissues is higher than the plasma b the surrounding tissue will swell with excessive fluids c near by cappilaries have become more pearmeable d B-lymphocyte will differeniate to become plasma cell

2. which of the following best describe the qualities of most antigens?

a macromolecules that are foreign to the host b atomic elements that are not normally present in the human body c macromolecules tah tare produced by the host organism d atomic elements that are harmful or toxic

3. an adbantages to adaptive immunity is

a its memory cell that provide quicker larger and more efficient immune response upon second exposure to an antigen b its need for several cells to be activated over several days on first exposure c the ability for its individul cells to respond to many differnt pathogens d the use of antibodies that cause cells lysis and kill invading cells

4, an advantages of innate immunity is

a its a barrier taht prevent pathogens from entering into the body b the specifcity of its individual cell which specialize in the removal on one type of antigen c the numerous step in the activation of its cell that can prevent autoimmune disease d the use of the antibodies to cause cell lysis and kill invading cell

5. B- lymphocytes are categorized as part of the adaptive branch of the immune sys for all of the following reason but one Which of the following is NOT one part of reason B lyphocytes are considered part of the adaptive immunity?

a they produce memory cell when activated b their receptors will bind to only one antigen c they require costimulation from an activated T helper cell d thet are a first line of defense that can begin killing

6. Over lap in the innate and adaptive immune sys is seen in all of the following examples but one Which of the following examples does NOT illustrate the over lap of innate and adaptive immune resposes ??? a dendritic cell presenting antigen on their MHC II proteins to T helper cells b macrophage becoming activated macrophages in response to cytokines realesed by T helper cells c natural killer cell causing of an abnoraml host cell lacking MHC proteins d Plasma cell that produce large amounts of IgE that will ultimetly allow mast cell to relase histamine

7. Which of the following examples below describe an autoimmune disease? a infection and death of T helper cells bya virus resulting in a loss of adaptive immunity b realse of bacterial endotoxins that block acetylcholine realse result is muscle paralysis c antibody binding to acetylcholine receptors of hte motor end palte resulting in muscle weakness.d uncontrolled cell division resulting in cell surface abnormalities recognized by natural killer cell.

8. Which of he following does NOT describe actions of interferon IFN? a virally infected cell can release interferon which attracts natural killer cell to attack and kill the IFN secreting cell b IFN binds to normal uninfected cell stimulating the activation of genes that produce anti viral proteins c IFN will attract macrophages to the secreting cell to be removed bt phagocytosis d IFN can penetrate the virla capsid and destroy the virus

HI HELP PLEASE I NEED ANSWERS TO ALL QUESTIONS PLEASE THANKS

1. during inflamation fluid will passively diffuse out of blod vessels into the nearby infected tissue. This implies all of the following EXCEPT

2. which of the following best describe the qualities of most antigens?

3. an adbantages to adaptive immunity is

4, an advantages of innate immunity is

6. Over lap in the innate and adaptive immune sys is seen in all of the following examples but one Which of the following examples does NOT illustrate the over lap of innate and adaptive immune resposes ??? adendritic cell presenting antigen on their MHC II proteins to T helper cells b macrophage becoming activated macrophages in response to cytokines realesed by T helper cells c natural killer cell causing of an abnoraml host cell lacking MHC proteins d Plasma cell that produce large amounts of IgE that will ultimetly allow mast cell to relase histamine

MIMM 214 Lecture Notes - Lecture 23: Phosphorylation, Mhc Class Ii, Cd154

Document Summary

Get access

Related Documents

MIMM 214 Lecture Notes - Lecture 24: Lymph Node, B-Cell Receptor, Clonal Selection

MIMM 214 Lecture Notes - Lecture 24: Phagocytosis, Cytoskeleton, Lymph Node

MIMM 214 Lecture Notes - Lecture 17: Cytotoxic T Cell, Lymph Node, Thoracic Duct

Related Questions