MIMM 214 Lecture Notes - Lecture 31: Somatic Hypermutation, Cytokine, Cell-Mediated Immunity
7 Jun 2018
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Lecture 32 – March 27, 2017
Memory
Protective Immunity
- Graph
- Early reinfection handled by performed Abs/effector T cells from primary, the previous response
- Late reinfection handled by immune memory B/T cells
- Memory is the hallmark of adaptive immunity
o Primary response is initiated upon first exposure to its antigen
o Memory lymphocytes are left behind after antigen is cleared
o A second exposure to the same antigen re-stimulates memory lymphocytes
o Reactivation yields faster more significant, better response
o Memory is not present in innate immunity
Immunological memory
- Ability of the immune system to respond more rapidly and more effectively on a second
encounter with an antigen
o Dependant on adaptive immune mechanisms
▪ Ag specific
▪ Memory responses occur after primary response (secondary, tertiary…)
lymphocytes initially generated late in the primary response
▪ Long lived
- In practical terms, resistance to a particular infectious disease upon re-exposure to the microbe
that causes that disease after having had that disease once before
o Or after being vaccinated
- The differences between primary and memory response
o More Abs, more cells
o Different Abs, different lymphocyte features
- The two main question sin the field of immunological memory are
o What are the unique features of memory cells?
o How is memory maintained?
Features of immunological memory
- Easier to detect/monitor for B cells than T cells
- Mediated by a small and steady number of memory cells
o Some of them proliferating at a given time
- Previous Ag exposure required
- Long lived
o Abs: no significant decline after a while
o T cells: gradual decrease
Question
find more resources at oneclass.com
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Document Summary
Early reinfection handled by performed abs/effector t cells from primary, the previous response. Late reinfection handled by immune memory b/t cells. In practical terms, resistance to a particular infectious disease upon re-exposure to the microbe that causes that disease after having had that disease once before: or after being vaccinated. The differences between primary and memory response: more abs, more cells, different abs, different lymphocyte features. Easier to detect/monitor for b cells than t cells. Mediated by a small and steady number of memory cells: some of them proliferating at a given time. Long lived: abs: no significant decline after a while, t cells: gradual decrease. Key results: more igg in secondary response, more rapidly activated. I(cid:374) pri(cid:373)ar(cid:455) respo(cid:374)se (cid:455)ou"d e(cid:454)pe(cid:272)t (cid:373)ore igm (cid:271)e(cid:272)ause you have the plasma blasts that secrete igm. In secondary response, you would get more igg. Conclusion: less reliance on innate, higher affinity in secondary response. Quantitative and qualitative differences in memory ab responses.
