MIMM 214 Lecture Notes - Lecture 3: Herpesviral Encephalitis, Tlr7, Tlr2
10 Sep 2018
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Induces formation of heterodimers (tlr-2 + tlr-1 or tlr-2 + Example with triacyl lipopeptide : two of the three lipid chains bind the to convex surface of tlr-2, while the third binds to the convex surface of tlr-1. Unc93b1: mutation leads to herpes simplex encephalitis but not impair immunity to many other viral pathogens (probabibly because of other viral sensor) Nemo for nfkb essential modifier: active ikk phosphorylates ikb, which releases nfkb -> induces transcription of genes in the nucleus coding for pro-inflammatory cytokines (tnf-alpha, il-1beta and. Aim2 pyrin domain: crystal may activate nalp3, autoinflammatory diseases : mutation in nod domain of nalp2 and 3, familial cold inflammatory syndrome and mucklewells syndromes : mutation in nalp3. 3-10: tlr + nod -> activate nfkb -> activates macrophages + dendritic cells -> release cytokines. + chemokines -> il-12 -> influence adaptive immune response: appearance of co-stimulatory molecules (called.
