MIMM 214 Lecture Notes - Lecture 17: Somatic Hypermutation, Immunoglobulin Class Switching, Alternative Splicing

• School: McGill University
• Department: Microbiology & Immunology
• Course: MIMM 214
• Professor: Joaquin Madrenas

Document Summary

Tcr diversification is concentrated on the cdr3s of tcr and chains. Cdr3 regions are on the variable domain of the tcr. Diversity in the molecules of human adaptive immunity. Stems from variability in and chains. Problem: 20,000 25,000 protein-coding genes in humans. Need to rearrange genes to form diversity. 1 allele codes for the chain. For and chain: specific v gene/j gene combination. For chain: specific v gene/d gene/j gene combination. Chain is the first gene that will be rearranged. Intervening dna between v/j or v/d/j loops out to be excised and degraded. The v/j or v/d/j become one transcriptional unit. The c gene follow the v domain. (gene conversion: not definitive evidence for humans) Proper gene rearrangement of h and l chain genes to give rise an ig that shows . Self-tolerance = negative selection (deletion) of autoreactive b-cells.