MIMM 214 Lecture Notes - Lecture 19: Mhc Restriction, Clonal Selection, Lymphocyte
5 Jan 2019
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Document Summary
In addition to antigen recognition, also need costimulation. Results in the delivery of signals to the lymphocyte that Will change the profile of gene expression on the lymphocyte. The changes in gene expression translate into changes in the phenotype of the lymphocyte that Ultimately correlate with proliferation and differentiation of that lymphocyte. Antigenic specificity: memory cell and effector cell. End regulatory step: apoptosis of effector cells. Mhc restriction: ag recognition restricted to peptides presented by self-mhc molecules. Allorecognition: <10% of t-cells in an organism show reactivity to foreign mhc molecules (with self or non- self peptides on their grooves) Signal transduction: translation of receptor engagement (binding) into signals to the cell. Cross-linking: binding of two or more receptors together. Phosphorylation/dephosphorylation: addition/ loss of p in a molecule, mediated by tyrosine or serine-threonine. Adaptor/scaffold molecules: molecules that facilitate the formation of molecular complexes around a receptor or another molecule. Signalling of cytoplasmic tail initiated by dimerization and transphosphorylation.
