MIMM 214 Lecture Notes - Lecture 22: Ionomycin, Co-Stimulation, Cd28

• School: McGill University
• Department: Microbiology & Immunology
• Course: MIMM 214
• Professor: Joaquin Madrenas

Document Summary

Heterodimer with help of cd3 and itams etc. Action shifted to transmembrane adaptors i. e. lat. To specific peptide: mhc complexes on apc or. Superantigens bound to mhc class ii molecules. Delivery of costimulation by cd28 or other costimulatory receptors. Cross-linking of cell surface receptors, e. g. cd3, cd2, etc. with: Non-specific cross-linking with natural molecules (e. g. lectins in mistletoe) Compounds activating signalling molecules (e. g. pma + ionomycin association) Delivery of costimulation by th2 cytokines or costimulatory receptors (cd40) Cross-linking of cell surface receptors, e. g. bcr and. Recombinant antibodies against igm ( made in the lab ) + lps. Intrinsic pathway of apoptosis triggered by intracellular stress and release of cytochrome c from mitochondria and regulated by proteins of the bcl-2 family. A key event of t-cell activation is transcription of the il-2. Gene and the il-2 receptor -chain (cd25) gene. Il-2 is a t-cell growth factor = t-cell proliferation.