MIMM 465 Lecture Notes - Lecture 5: Immunoglobulin G, Relative Risk, Cirrhosis
16 Apr 2013
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Document Summary
Viruses and hematology: a quest for a cause-effect relationship. The following are some viruses that have been linked to blood diseases. Human t-lymphotropic virus 1 linked to some leukemia: htlv-3 alias hiv. Host, immune control and virus: new strategy for patient management. 1909: ellerman and bang in copenhagen transmitted leukemia in chicken through cell free, filtered extract suggested infectious etiology. They take liquids from the tumor of a chicken. They were able to induce tumors into other chickens by giving them this liquid even though it was filtered and the liquid itself did not contain any tumor cells. 1911: rous usa transmission of chicken sarcoma by use of filtrates. 1973: diamandopoulos simian virus (sv40) can induce leukemia in certain experimental conditions: oncogenic virus can promote malignancies in several animals. Can induce cell growth by anti-apoptosis, bcl2 . 1952: denis burkitt described specific childhood lymphoma in uganda, closely related to malaria. Rare tumor in the lymph node by the jaw.
