NEUR 310 Lecture Notes - Lecture 5: Integrin, Eph Receptor B2, Retina

• School: McGill University
• Department: Neurology and Neurosurgery
• Course: NEUR 310
• Professor: Jean- Francois Cloutier

Document Summary

Review: growth cone detects and responds to axon guidance cues. There are different types of chemical cues that act in both short and long range distance. Extracellular matrix molecules: can promote neurite outgrowth, allows adherence of neurons to extracellular matrix, coated a cultured dish with collagen, which are only present in corridors separated by inert metal plates. Show that axons prefer to grow where there is collagen - growth cones extend only on the collagen-coated surface. Integrins are receptors that can bind to laminins: found on the surface of axons, link between the actin filaments inside the growth cone and the extracellular matrix, heterodimers of a(cid:374)d subunits. Integrins differ in the laminins with which they interact. Intracellular domain of integrins bind to cytoskeletal co(cid:373)po(cid:374)e(cid:374)ts such as -actin and talin. The retina contains lots of laminin, which acts as the growth promoting substrate for axons. Two broad categories of cams: calcium-dependent cell adhesion molecules, e. g.