NEUR 310 Lecture Notes - Lecture 14: Gria4, Chemical Synapse, Adenosine Deaminase
11 Apr 2017
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Document Summary
Most excitatory synapses in the brain contain ampa and. Both ampa and nmda receptors are tetramers: each one of the subunits are proteins (like the potassium channel, the ion conduction pore is located in the center. Nmda receptors: comprised of glun subunits, 2 glun1 subunits + 2 glun2 subunits required for functional receptors, associates with four different glun2 subunits (a, b, c, d) Similar to the potassium channels - but instead of. The glutamate is staying bound to the receptors, but the ion channels would close. Same with the ampa receptors as well, they desensitize. The pore of the nmda receptor is highly permeable to ca2+ ions. Kainate receptors: kainic acid is a neurotoxin derived from seaweed, selective activator of gluk glutamate receptors, gluk1-3 subunits can form homotetramers, gluk4 and gluk5 cannot form functional channels alone, but modulate the function of receptors formed by gluk1-3. Still don"t really know their function in the brain.
