NEUR 310 Lecture Notes - Lecture 20: Autophosphorylation, Gria1, Brenda Milner
11 Apr 2017
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Classical associative (pavlovian) conditioning: unconditioned stimulus (us) --> unconditioned response (ur, conditioned stimulus (cs) does not evoke ur, after pairing us + conditioned stimulus (cs): cs --> ur(cr) Idea of changing a single synapse is the most intuitive. What properties are required of a physiological basis for memory: persistence, basis of a memory is that it is long-lasting. Is maintained for a long time following a rapid induction. Induced only at appropriately stimulated synapses, and not neighbouring synapses of synaptic activity: e. g. only the bell will induce drooling, not all other sounds, associativity. The rodent hippocampus: much plasticity research uses the hippocampus. It"s strongly implicated in learning and memory in both humans and animals: easy to apply simple cell biological tests due to its particular wiring. In 1953, to treat severe epilepsy, had the bilateral removal of his hippocampi and medial temporal lobes: could not form new declarative memories, studied by brenda milner (of the mni)
