NSCI 400D1 Lecture Notes - Lecture 1: Sleep Disorder, Autophagy, Hela

• School: McGill University
• Department: Neuroscience
• Course: NSCI 400D1
• Professor: Per Jesper Sjostrom

Document Summary

2nd most in uential neurology disease caused by degeneration of dopaminergic neurons in midbrain. Only some motor symptoms can be treated by dopamine genes. Lrrk2 (dominant) what"s wrong with these gene? pink1 encodes mitochondrial kinase (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) Null mutant have dopaminergic defects, and muscle degeneration & cell death. Muscle and mitochondrial defects in pink1 null mutants. Mitochondria are undergoing cell death in mutants (cid:12254) Because in early stage there is no di bw wt and mutant. Fly mutants analogous to human pink1 disease mutation show similar phenotypes to pink1 null. Is study in drosophila relevant to human? human and y genes perform similar roles. Patients w pink1 or parkin mutates are indistinguishable to y"s symptom mitochondrial morphology is maintained by dynamic balance bw fusion and ssion mitofusin kd or drp1 overexpression results in mitochondrial fragmentation.