PARA 438 Lecture Notes - Lecture 5: Cytotoxic T Cell, Hapten, Immunogen
25 Oct 2018
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Immunogenicity: ability to induce a humoral / cell-mediated immune response. Exception: hapten, can"t induce this (no final product) Antigenicity: ability to combine specifically with final products of the above responses. T or f: all molecules that have the property of immunogenicity also have the property of antigenicity, reverse if true. Hapten is incapable to induce a full immune response + lack immunogenicity. Coupling to a large protein [carrier] --->can cause immunogenic response. When absorb through skin, urushiol undergoes oxidation + generate hapten called quinone; quinone reacts with skin protein to form a hapten-carrier [quinone-skin proteins] First exposure: followed by proliferation of effector t cell. Second exposure: proliferation of activated t cells + generate immune reaction which produce typical blister. Foreignness: degree of foreignness decide degree of immunogenicity. Chemical composition and heterogeneity: synthetic homo-polymers composed of multiple copies of single aa / sugar tend to lack immunogenicity regardless of their size.
