PARA 438 Lecture Notes - Lecture 10: Selectin, Endothelium, Chemokine
25 Oct 2018
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Roll and attach to the cell and find the right spot to leave (which include adhesion) P selectin: activated platelets + endothelial cell (cover lumen of bld vessels) Number of consensus repeats: make the selectin different. In order to get into lymphoid tissues and may encounter ag. Chemotaxis (movement of a motile cell) for leukocyte. 4 r subgroups ------ 1) cxc 2) cc 3) c 4) cxxxc. Very similar structure to cytokine but diff by number of cystine. Bind to r by coupling with heterotrimeric large g protein which activate signal pathways result in modification in physiology of target cell. Both are used with route preferences that switched by environment. Docking structures: transmigratory cups (full of integrin + ligands) Found in patient lacking cd 18 ----frequent infection. Lymphocyte recirculation leave bld --->lymph nodes through high-endothelial venules (hevs) Go to spleen and got back to bld.
