PARA 438 Lecture Notes - Lecture 13: Immunoglobulin M, Immunoglobulin G, Cytokine
25 Oct 2018
School
Department
Course
Professor
Document Summary
Immature bc (in bone marrow) ---> express membrane igm----become mature na ve bc (only 10%---apoptosis: no immune response) when reach bld stream ----then express migm + migd. Na ve bc die in peripheral, unless meet ag + activated by th cell. Ag a (first ag) ---igm: the first ab appears after immunization. Second ag (can be the same type of ag)----meet igm first, igm is slower. Secondary response: have a second encounter with same ag. Very rapid and intense response -----if memory cell present. Need th cells: direct contact (need the cytokine) Type 1 & type 2: divided by diff mechanisms. Need to know this for type 3 questions. 1st signal: ag attach bcr (igm on the surface) Ab can do 3 things to the bacteria: Complement activation: ab activate complement which enhance opsonisation + lyses bacteria. Tc dependent ag = require th to produce ab; unable to induce ab without tc.
