PARA 438 Lecture Notes - Lecture 18: Type I Collagen, Mast Cell, Interleukin 4
31 Oct 2018
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Pathway: sensitization + re-exposure (influenced by genetic & environment) Ingested / injected: severe symptom life-threatening, systemic reaction (ex. epipen) Most relevant 54%: seasonal allergy, asthma, eczema, food allergy. B cell = plasma cell + memory cell; ige goes to bld and periphery and coated on mast cell by fceri r [sign of end of sensitization phase] 2. re-exposure [symptomatic] (early & late response: minutes to hours) Pollen touches the skin (periphery) + allergen cross-link ige on surface of mast cell causes degranulation and. Early response: activate pro-inflammatory mediators i. ii. iii. Histamine: bind h1 r; smooth muscle contraction + bld vessels vasodilation + swelling. Protease: cleave complement protein into peptide--cause inflammation; stimulate mucus secretion. Late phase: tc, eosinophil, basophils activate pro-inflammatory mediators i. ii. Leukotrienes: smooth muscle contraction + chemoattractant (can"t breathe) Mild symptom (inhaled/ contacted): antihistamine (sm contraction + vasoconstriction) [early]; corticosteroid (decrease pro-inflam cytokines) [late]; leukotriene blockers [late phase]
