PARA 438 Lecture Notes - Lecture 20: Adoptive Cell Transfer, Cell Therapy, Autoimmune Disease

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Only recently the immunotherapy of cancer has meet the success. Cancer: describe tissue of cells have multiplying abnormally. Adenoma: benign tumor of granular tissue; can be removed by surgery. Adenocarcinoma: malignant tumor of granular tissue; invasive, structure of tumor is broken and cancer cells spread into bld and body. Ag of cancer show have molecules on the surface of tc to show + /- selection. Lymphoma: cancer of solid lymphoid tumors (hodgkin disease) Tsta [tumor specific transplantation ag]= tra (tumor rejection ag): unique, not occur on normal cell. Tata:[tumor associated transplantation ag] inappropriate expression of embryonic gene; or protein expressed at very low levels on normal cell but expressed at higher level on tumor cells. Gene in me, some are suddenly turned on. Inject inbred mouse (to match host and tumor for mhc type) irradiated tumor cells: If tumor cell doesn"t grow, then subsequent injection of same tumor cells won"t grow as well -- protected.

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