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Class Notes for Parasitology at McGill University

PARA 438 Lecture Notes - Lecture 21: Adaptive Immune System, Immunity (Medical), Edward Jenner
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Nov. 5+7 - Vaccines November 5, 2018 1:34 PM Clinical sign: smallpox (head, hands, legs); after the 1st exposure, people are not susceptible anymore - Cause mild reaction, not disease Edward Jenner - Smallpox ...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 23: Giardia Lamblia, Antimicrobial Peptides, Transporter Classification Database
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Nov. 12 - immune response to parasites November 12, 2018 1:33 PM Unicellular - worms Parasite: an organism that lives on or in a host and gets its food from or at the expense of its host Nematodes(roundworm),cestode...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 19: Autoimmune Disease, Cd28, Clonal Anergy
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Oct. 31 - Tolerance autoimmunity October 31, 2018 11:59 AM Tolerance: mechnism to protect one individual from portntially self-reacting lymphocyte 1. Central tolerance: primary mechanism, delete TC BC before maturation if...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 20: Adoptive Cell Transfer, Cell Therapy, Autoimmune Disease
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Nov.2 - Tumor Immunology November 2, 2018 1:36 PM Only recently the immunotherapyof cancer has meet the success Cancer: describe tissue of cells have multiplying abnormally Adenoma: benign tumorofgranular tissue; can be re...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 18: Type I Collagen, Mast Cell, Interleukin 4
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Oct. 29 - hypersensitivity (Allergy) October 26, 2018 3:38 PM Hypersensitivity = immune reaction to harmless ag - Source: pollen, dust, food, drugs - Pathway: sensitization + re-exposure (influenced by genet...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 17: Transplant Rejection, Ciclosporin, Skin Grafting

Oct. 24&26 - Immunity in transplantation and pregnancy October 24, 2018 1:36 PM MHC: 1) binds peptide frag of AG present to APC. 2) MHC = genetic gene complex to accept / reject transplanted tissue (from another mem...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 13: Immunoglobulin M, Immunoglobulin G, Cytokine

Oct. 15 - Humoral Immune response October 15, 2018 1:08 PM Immature BC (in bone marrow)---> express membrane ...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 14: Complement System, Complement Membrane Attack Complex, C3B

Oct. 17 - The Complement system* October 17, 2018 12:37 PM Very important protein in the plasma Complement - Plasma protein to opsonize pathogen + induce inflammation Make macrophage easy in the job -...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 12: Rudolf Virchow, Louis Pasteur, Nitric Oxide

Oct. 12 - inflammation October 12, 2018 1:33 PM Inflammation - Disease characterized by: heat, redness, edema, pain by Cornelius Celsus Rudolf Virchow: + another characteristic: leading to loss of function Louis P...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 15: Nude Mouse, Inbred Strain, Umbilical Cord

Oct. 19 - Experimental system/immunologist's toolbox October 19, 2018 1:45 PM Experimental animal models How to choose animal? By suitability to obtain a research goal - Ex. Immunologymice. Why choosemice? ...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 10: Selectin, Endothelium, Chemokine

Oct. 3 - Leukocyte activation & migration October 3, 2018 1:05 PM To emigrate.we need Selectin mediates Tethering and rolling [1st...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 16: Pumpkin Seed Oil, Immunoglobulin Class Switching, Cod Liver Oil

Oct. 22 - Nutrition immune system October 22, 2018 1:35 PM The volume counts Obesity is almost the same compare to US Obese individual: - lower lymphocyte capacity; lower NKC activity - Over all diminish immune response A...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 11: Immunogenicity, Mhc Class Ii, Mhc Class I

Oct.5 - Review session October 5, 2018 1:35 PM CD4 8 3 difference? - Is CD3 a signal for activating TC? Definition? - On surface protein, at against surface protein, make them able to attach it - Cytokine accessory prote...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 5: Cytotoxic T Cell, Hapten, Immunogen

Sep.17 - Antigens & Antibodies September 18, 2018 12:31 PM Immunogenicity vs. Antigenicity - Related but distinct Immunogenicity: ability to induce a humoral / cell-mediated immune response - Exception: Hapten, ca...

Parasitology
PARA 438
Gaétan Faubert
PARA 438 Lecture Notes - Lecture 7: Immunophenotyping, Humoral Immunity, Cell-Mediated Immunity

Sep. 21 & 24 - TCR, TC development + MHC September 26, 2018 12:37 PM Cytotoxic C: killing cell Immunophenotyping: - Isolate one CD and inj...

Parasitology
PARA 438
Gaétan Faubert

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