PHAR 300 Lecture Notes - Lecture 14: Fentanyl, Diazepam, Desflurane

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Introduction: general anesthesia involves interfering with the major conscious function of the brain. It has been replaced by halothane in 1956 also a volatile anesthetic: other drugs are also available, microsurgery: delicate surgery (i. e. nerve surgery) Induction agents: induce unconsciousness: anesthetic gases and volatile agents: maintain unconsciousness, analgesics: abolish pain (before, during and after, muscle relaxants: relax muscles reversed after operation is finished, reversal agents: reverse muscle relaxation. Inhalational anesthetics: end in ane halothane, isoflurane, enflurane, sevoflurane, equipment: blood gas monitor, anesthetic gas regulator, ekg and bp readout. Pharmacokinetics of inhalational anesthetics: molecules of drug in gas phase along with oxygen, lungs have a huge surface area for absorption, drug delivery determined by partial pressure of anesthetic in gas, partial pressure ~ concentration, e. g. Nitrous oxide: 70% concentration (x 760) = 532 mm hg. Oxygen : 25% concentration (x 760) = 190 mm hg. ____ halothane: 5% concentration (x 760) = 38 mm hg____