PHAR 300 Lecture Notes - Lecture 4: Reactive Intermediate, Morphine, Treatment As Prevention
Document Summary
Magnitude of drug effect: the magnitude of a drug"s effect is dependent on: Pharmacodynamics what receptors the drug acts on. Pharmacokinetics how the body has an impact on the drug. In reality, immediately after injection the drug will be found most concentrated in organs with high blood flow (heart, liver, kidneys, lungs and the brain if it"s lipid soluble). With time, the drug will be evenly distributed throughout the body. The drug is not only being dissolved and transported by membrane proteins. There are also specific transport proteins that transport foreign substances. P glycoprotein is a common one that removes antibiotics out of the cell. Transporters to get drugs into the cell have been discussed, but there are also proteins involved with removing drugs from cells. Volume of distribution: the central volume of a drug at the site injection will come out towards other tissues with time, volume of distribution (vd) =