PHAR 300 Lecture Notes - Lecture 4: Loading Dose, Sorosis, Automobilclub Von Deutschland
25 Sep 2018
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Document Summary
Today"s lecture focuses on chapters 2 and 3. Magnitude of drug effect = pharmacodynamics + pharmacokinetics + individual biological properties. Two-compartment model: drug distributes evenly in the body, blood flow to different parts of the body varies. Compartment 1: the high blood flow regions. Compartment 2: the rest of the body. Compartment 3: low blood flow tissues: this is more like real life. Continuous infusion causes build-up in lipids, bone, hair, etc. Liposoluble drugs store in fat (effect is slowly released by lipid into bloodstream, ex: anaesthesia) There is elimination of the drug, particularly in the high blood-flow compartment, which the kidneys and the liver are part of. Cells have different properties: differ in structure, receptors, the amount of the receptors, transport mechanisms. Ex: p glycoprotein are anti-drug pumps: they kick the drug back out of the cell. Way to quantify drug distribution, even tells us where the drug goes. Theory: we inject a certain amount of drug.
