PHAR 300 Lecture Notes - Lecture 13: Periaqueductal Gray, Opioid Peptide, Opioid Overdose
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Is a dangerous effect due to loss of water and electrolytes. Morphine: makes you sleepy (named after morpheus) Opiates can act in other regions of nervous system and depress ans. 1975: discovery of endogenous opioids: made by the body from 3 precursors: 3 types of opioid receptor (vs 2 for cannabinoids) Antagonist like naloxone to help with overdose. The inhibited pathway can also be inhibited. Receptors accompanied by natural ligands that stimulate them. People can alter emotional reaction to pain. Mu is the crucial repector: gp-coupled. Lower amount of transmitter from presynaptic side and open k+ channel in the post-synaptic. All classical opiate drug of abuse (morphine, heroine) target mu receptors. Delta and kappa don"t produce much analgesia and kappa have an aversive reaction. Homodimers (2 of same), heterodimers and monomers form different receptor combinations. Heterodimers with different properties combining two delta and two kappa don"t respond much while delta and kappa might respond strongly.