PHAR 301 Lecture Notes - Lecture 15: Sumatriptan, Ergotamine, Triptan

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Moskowitz ma (1992), neurogenic vs. vascular mechanisms of sumatriptan and ergot alkaloids in migraine, trends in. Pharmacological sciences 13:307-311: although now quite old, it is a useful general review of mechanisms, he discusses many of the experiments described in lecture. S diamond (2001), a fresh look at migraine therapy. 109: 49-60: no need to read about drug classes not mentioned in lecture. People have been trying to get rid of migraines for years. Trepanning: drilling a hole through the skull to release evil spirits. The ancient greeks would stand over piles of coffee beans and inhale the smoke. The patient may have a prodromal phase (warning signs); a sign that a headache is coming. 1 in 5) get an aura, a strange sensation, followed by the headache. It is in the top four most disabling disorders. Two or more headaches preceded by aura (lifetime) Flashing lights or zig-zag: missing area of visual field (i. e. scotoma)

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