PHAR 301 Lecture Notes - Lecture 17: Ic50, Sedation, Orthostatic Hypotension

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Nat = net = noradrenaline (i. e. norepinephrine) transporter. Antidepressants appear to work by increasing na and/or 5ht transmission in the brain. Antidepressant drug classes differ little in clinical efficacy but differ much in their adverse effects. Depression is common and debilitating; antidepressant drugs are widely prescribed. It is mostly untreated and often no recognized: ~10% of people suffer from depression in a given year. Who: the global burden of disease in 2004 and 2030 (projected: unipolar depressive disorders is #3 on the scale of global burden of disease. It is projected to be #1 in 2030. Major depression - an affective disorder: definition: affect = mood, typical symptoms. Dsm-v; major depressive disorder: depressed mood. Unipolar vs. bipolar: different illnesses: major depression is unipolar - it is much more common and has less of a genetic component to it, don"t know if unipolar is due to a single disease or multiple diseases.

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