PHAR 303 Lecture Notes - Lecture 20: Seminiferous Tubule, Corpus Luteum, Leydig Cell
2 Apr 2017
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Phar 303 lecture 20: reproductive toxicology (robaire) Begins at fertilisation of egg zygote. D7 in rats and d6 in mice implantation. Followed by embryogenesis identification of all tissues. Variable lactation window: 2wks in rodents and 6-24mo in humans. Toxicants can affect any stage of development and will therefore have a wide range of effects on both mother and offspring. Fertility gametes to zygote: gametogenesis, fertilisation, transport and implantation. Segment 2 implantation, embryogenesis, fetal development and parturition. Segment 3 lactation, postnatal development, growth and sexual maturation. There is a block in the first meiotic division that is lifted as the follicles develop followed by a second meiotic division allowing for the release of the egg. Fsh and lh are important in driving this process: primordial follicle = egg surrounded by single layer of granulosa cells, it becomes the primordial follicle when the number of surrounding layers increases.
