PHAR 303 Lecture Notes - Lecture 17: Distal Convoluted Tubule, Renal Function, Capillary Pressure
15 Feb 2018
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Document Summary
One of the major renal toxicants is mercury, but there are many other chemicals that can cause kidney damage. The kidney allows for elimination of metabolites and parent compounds from the body: this makes it very important for getting rid of toxins, this means that it will be more exposed to toxins that most other organs. Excrete metabolites, xenobiotics (drugs/toxins and their metabolic products) Regulate bp, secrete hormones (to regulate bp, rbcs, etc. ) Creatinine: can be measured in the blood and the urine, creatinine is filtered by the kidneys and not reabsorbed, which allows for rapid evaluation of kidney function. The kidney is vulnerable because it has a high blood flow (so any toxic compound in circulation will get to it) and it serves an excretory function (can concentrate toxins while eliminating them) The kidney receives 21% of the co (1. 2l/min: they are only 0. 04% of body weight, but require a lot of blood flow.
