PHAR 303 Lecture Notes - Lecture 3: Glycine Receptor, Phorbol, Saxitoxin
27 Jan 2016
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Document Summary
Toxicants are usually small molecules that weigh less than 300- They interact with the target (dna, proteins, membrane, lipids) There are two different methods of drug delivery o. Either the cell dies or a new protein has to be made again to replace the previous one. Action by: hydrogen abstraction, electron transfer, enzymatic o o reaction. Nucleophilic positions on cellular macromolecules: the arrows show most likely sites for electrophilic attacks, modifying dna is dangerous, the dose-response relationship. Analysis of dose-response curves o o o o o doses and small responses (i. e. near the origin) Usually curved or s-shaped with peculiarities in the region of low. Can be individual (graded) or quantal (population) relationships. Minimum dose for observable effect is the noael (no observed. When no effect is observed after a certain dose, that dose adverse effect level) is considered a safe level. Usually they put down the noael by a factor of 1000 to identify a safe, non-toxic exposure level.
