PHAR 303 Lecture 8: The –omics Revolution and Epigenetic Mechanisms in Toxicology
10 Feb 2016
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Lecture 8: the omics revolution and epigenetic mechanisms in toxicology. New measures o o o o o o. Determine whether gene, rnas, protein or metabolite expression profiles or. signatures can serve as markers to predict toxicology. Genomics: the study of all of the genes of a cell or tissue at the dna level. Epigenomics: the study of all epigenetic modifications, e. g. reversible modifications on a cell"s dna or histones that affect gene expression without altering the dna sequence. Transcriptomics: the study of all of the gene transcripts of a cell or tissue (rna level) Proteomics: the study of all of the proteins of a cell or tissue. Metabolomics: the study of all small chemicals in a cell. Toxicogenomics: the effects of a toxicant on all of the genes of a cell or tissue at the dna, rna, and protein levels.
