PHAR 303 Lecture Notes - Lecture 10: Polycyclic Aromatic Hydrocarbon, Ethyl Methanesulfonate, Phorbol

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Dysregulation of the balance between cell proliferation and cell death. 70-90% have a linkage to environmental, dietary and behavioural factors. A carcinogen is any substance, radionuclide, or radiation that is an agent directly involved in. This may be due to the ability to damage the genome or to the disruption of cellular metabolic. There is a lot of proof required so name something as a carcinogen. Some of these substances are not a carcinogen by themselves - they have to be metabolically. Percivall pott (1714-1788): cancer of the scrotum among chimney sweeps (exposure of the skin to activated. History of chemical carcinogenicity soot and coal tar) 1816: application of coal tar on rabbit ears produced skin cancer. Nongenotoxic - change how information is expressed from dna. Non-genotoxic alters gene signaling and regulation o o. Croton tiglium - a source of phorbol esters. Initiation: start off with a normal cell and cause dna damage.

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