PHGY 209 Lecture Notes - Lecture 10: Prothrombinase, Roman Numerals, Vitamin K Deficiency

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Etiology: deficiencies of vitamin b12 and folic acid. Both required for normal synthesis of dna. Initial stem cells are nucleated so this applies. Larger than normal: normochromic 33, folic acid. Overcooking vegetables throws out the water which contains it: vitami b12. Eaten and combines with the intrinsic factor: forms a if-b12 complex. Goes to small intestine and ileum is where its absorbed: there are receptors there. Cells are larger than normal and more rapidly destroyed: survival disorders. Hemolytic anemias: may be accompanied by jaundice. Ex hereditary spherocyotsis (spherical rbc instead of dumbbell, rigid) Sickle cell anemia: single amino acid in the chain of globin is abnormal, tend to precipitate, clog up the small capillaries. Thalassemia: deficient synthesis of globin amino acid chains, acquired. Internal: accumulates into the tissue called hematoma. A number of interacting, overlapping mechanisms: vascular response. Constriction and minimization of blood flow in injured area: platelet response. Temporary decresing blood flow: clot formation.

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