PHGY 209 Lecture Notes - Lecture 14: Tetraodontidae, Sodium Channel, Phyllobates

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14 Nov 2016
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Transduction of pressure on skin surface into neuronal activity: more pressure on skin = greater frequency of action potentials. Puffer fish: tetrodotoxin (ttx) (binds to the sodium channel opening, plugs it up so your neurons can"t fire action potentials; diaphragm muscles can"t contract, you"d stop breathing). Very potent toxin, 10-8 mol of this toxin can block all your sodium channels. Phyllobates frogs: batrachotoxin, a powerful sodium channel activator (makes them irreversibly opened; open all the time). Your teeth are full of pain neurons but when you get local anesthetic, the sodium channels there are blocked, no action potentials fired, you don"t feel any pain. When you have epilepsy, you want to stop it without putting you to sleep. When you touch a hot stove, you feel a sharp pain that makes you pull your hand away. However, if you don"t retrieve your hand, and stay, after about 10 hand away.

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