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Lecture

Endocrinology- Lecture 1


Department
Physiology
Course Code
PHGY 210
Professor
Ann Wechsler

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Lecture One- Monday, January 4th, 2010
MIDTERM EXAM: Monday March 8th, 6:30pm-8:00pm (30 MC, 30%)
ENDOCRINOLOGY:
-Endocrinology is self attenuating (eg: negative feedback loops).
-The essence of endocrinology: it’s all about communication.
COORDINATION OF PHYSIOLOGICAL PROCESSES:
-In a living organism there must be coordination of number of physiological
activities taking place simultaneously such as: movement, respiration, circulation,
digestion, excretion and metabolism.
-Endocrine system and Nervous system both signal anatomical parts of the
body.
-The central nervous system and the endocrine system represent the two
major means by which these functions are coordinated.
LONG DISTANCE COMMUNICATION:
-Communication between cells that are not in contact is achieved through a
number of chemical substances (hormones), which are secreted by releasing cells
and interact with specific receptors on distant target cells (bind to them).
-Signaling through these receptors leads to a specific physiological effect.
-Cells of the immune system release factors that act in a hormonal way (eg:
cytokines). Therefore what we learn about endocrinology can apply to other parts of
the body as well!
-Hormones are secreted into the blood by an endocrine gland and the
hormone is transported by the blood to a distant target site.
NEUROENDOCRINE SIGNALING
-Signals from the brain transmitted to the hypothalamus lead to release from
the hypothalamus (neuronal tissue) of hormones which travel down system of blood
vessels and eventually impinge upon pituitary cells and hormones released signal the
release of pituitary hormones.
-Anterior pituitary is endocrine, and the posterior pituitary is neuronal.
see picture in slides
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