PHGY 210 Lecture Notes - Lecture 6: Respiratory Alkalosis, Metabolic Alkalosis, Respiratory Acidosis
15 Feb 2018
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By glutamine metabolism with nh4, by h+ secretion and excretion on nonbicarbonate buffers (such as phosphate). Again, h2o and co2 form h+ and hco3-. Hco3 goes into body and h+ is secrted into limen. No hco3- to combine with, so binds to phophate, hpo4-2 and secreted. This process is also called h+ excretion bound to nh3 . Glutamine coming from interstitial fluid and from the lumen after being filtered (symporter with na) go in the cell. It is broken down into hco3-, which is absorbed and. Nh4+, which is secreted into lumen and secreted. Both processes could be viewed as h+ excretion by the kidney. Lecture 6 hydrogen ion regulation and diuretics and kidney disease. The urine is highly acidic (lowest attainable ph = 4. 4). Responses to alkalosis (low h+ concentration: rate of h+ secretion is inadequate to reabsorb all the filtered hco3.
