PHGY 210 Lecture Notes - Lecture 1: Luteal Phase, Activin And Inhibin, Endometrium

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20 Jul 2016
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Fsh stimulates granulosa cells of follicles to proliferate -> production of estrogen, which further stimulates granulosa cell proliferation: day 8, one follicle becomes dominant and committed to further development. In humans, how one follicle becomes dominant still unknown: dominant follicle produces increasingly more estradiol, which becomes important in late stages of cycle. increasing estradiol stimulates uterine endometrium proliferation, by day 13, the endometrium very thick. Lh synthesis by anterior pituitary known as estrogen +ve feedback control mechanism. o thus, estrogens exert -ve feedback - decreased gnrh and lh release and. +ve feedback increased sensitivity of anterior pituitary cells to gnrh and increased lh synthesis. o meanwhile, at the ovary the follicle has become huge. In addition, under the influence of progesterone the endometrium becomes glandular. The endometrium is now fully prepared to receive and support the development of a growing embryo: luteal phase o no fertilization - egg degenerates, corpus luteum degenerates (luteolysis).

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