PHGY 212 Lecture Notes - Neutrophil, Immunoglobulin M, Hemagglutination
16 Dec 2012
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Document Summary
To produce a large repertoire or cells able to recognize and respond to. Also recognize self but don"t respond to it. Spleen, lymph nodes, mucosal associated lymphoid tissue (malt), bronchial associated lymphoid tissue (balt), tonsils, adenoids, peyer"s patches gut associated lymphoid tissue (galt) Provide an environment for cell-cell interaction and cytokine cell interaction. Stem cell - can proliferate into any cell. Lymphocytes (b cells, t cells, natural killer cells) arise from lymphoid stem cells. T cells kill virally or bacterially infected cells. The way b cell recognizes antigen is that they have receptor on surface that has specific antigen combining site that recogni zes antigens from other antigens. Antigen and receptor engulfed by b cell --> will get broken down in b cell. Some antigen gets broken down into fragments (8 -12aa) that makes a complex with mhc molecules. Everybody will have slightly different mhc (also called hla) All peptides recognized are amount the same size 8 -12aa.
