PHGY 311 Lecture Notes - Lecture 4: Neuropathic Pain, Bumetanide, Na-K-Cl Cotransporter

• School: McGill University
• Department: Physiology
• Course: PHGY 311
• Professor: ellis cooper

Document Summary

The resting potential is governed by ion channels that are in their open state allowing the flow of ion (na+ and ca++ in, k+ and cl- out). The net flow of these ions is 0. It is a balance of the ions flowing in and out. There are no channels allowing calcium in at rest. The chloride gradient equilibrates at rest so there is no driving force pushing chloride out. At rest, these cells have a membrane potential of -15mv. The non-selective current equals 0 (ins = 0). Most excitatory neurotransmitters receptors are non-selective cation channels. For many neurons at rest, cl- is not in equilibrium with the resting potential. Na+/k+ cotransporter allows the other pumps to have the required energy. K/cl cotransporter cl- out of the cell. Gaba a receptor cl- in the cell. When these synapses fire, they open the chloride channels. Cl- gradient are different in embryonic neurons and adult neurons.