PHGY 313 Lecture Notes - Lecture 10: Absolute Neutrophil Count, Cfu-Gemm, Lymphopoiesis
24 May 2016
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Document Summary
Hsc gives rise to common lymphoid progenitor (clp) and common myeloid progenitor (cmp) Progenitor (gmp) o: clp b/t/nk cells, cmp megakaryocyte erythroid progenitor (mep) & granulocyte monocyte o, mep megakaryocyte & rbcs, gmp granulocytes (baso/neutro/eosino) & monocytes. Most abundant type of white blood cells: 50-70% of white blood cells. Normal absolute neutrophil count 1500 8000 / mm3. Short-lived cells 10 hours to 5 days. Rapid migration to the site of infection and inflammation: Activation in response to pathogens and their products: Killing of pathogens: phagocytosis, oxidative burst, non-oxidative killing. Neutrophil recruitment to the site of infection: o o o: rolling of neutrophils along inflamed vascular endothelium: Inflamed vascular endothelium expresses proteins selectins p and e. Neutrophils adhere to these proteins using (esl-1), (psgl-1), and cd44: adhesion of neutrophils to endothelium and extravasation: Adhesion proteins integrins such as lfa1 on neutrophils binding icam1 and other ligands on vascular endothelium.
