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Physiology (903)
PHGY 210 (301)
Ann Wechsler (112)
Lecture

phgy 210, kidney summary +SOS notes.docx

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Department
Physiology
Course
PHGY 210
Professor
Ann Wechsler
Semester
Winter

Description
KIDNEYisbehindperitoneumonbothsidesofvertebralcolumnagainstposteriorabdominalwall150geachregulationofwaterinorganicionsandacidbasbalanceremoveofmetabolicwastesureafrombloodandtheirexertionintheurineremovalofforeignchemicalsfrombloodandeliminateitwithurinedrugsproductionofhormonesenzymesaerythropoietinhormonecontrolserythrocyteproductionbreninenzymecontrolstheformationofangiotensinandinfluencesbloodpressureandsodiumbalancec125dihydroxyvitaminDactivevitaminthatinfluencesCabalanceRenalarteryinterlobararteryarcuatearteryinterlobulararteryafferentarterioleglomerulusefferentEachkidneyhas1millionnephronseachconsistsofrenalcorpuscleGlomerulusBowmanscapsuletubuleGlomerulusBowmansCapsuleproximalconvolutedtubuleproximalstraighttubuledescendingthinlimbofHenlesloopascendingthinlimbofHenlesloopthickascendinglimbofHenlesloopmaculadensaheredistalconvolutedtubulecorticalcollectingductmedullarycollectingductBowmanscapsuleconsistsofparietallayeroutsideoneandviscerallayerinsideonemadeofpodocytesInglomerulusarteriolesareverytighttoeachotherplustheyaresurroundedbythosepodocytesandtheircellprocessesFiltrationbarrierconsistsofvisceralglomerularepithelialcellspodocytesGBMendothelialcellsFromcapillaryendothelialfenestrabasementmembranefiltrationslitsofpodocytesBowmanscapsuleUrineformation1GlomerularfiltrationUrineformationbeginswithfiltrationofplasmafromglomerularcapillariesintoBowmansspaceglomerularfiltration2TubularreabsorptionfromtubulesperitubularcapillariesParaandTranscellularmoreregulatableDiffusionisParacellularinbwtubularepithelialcellsoftenacrosstightjunctionsconnectingthetubularepithelialcellsDependsonconcentrationgradientegUreaisfreelyfilteredatglomerulusinproximaltubulewaterreabsorptionoccursureaconcentrationbecomeshigherureadiffusesintointerstitialfluidandreabsorbedbyperitubularcapillariesMediatedtransportexclusivelybytranscellularthrutubularepithelialcellsrequiresassistanceoftransportproteinsoftencoupledtosodiumreabsorptionNaisactivelypumpedtoperitubularcapbyNaKATPasesoNaAAglucosefreelydiffusesfromtubularlumenintocellusingsymportsTransportmaximumamountofsubstancethatcanbetransportedatanyonetimeWhenallthetransportersaresaturatedoccupiedthennomoresolutecanpassthroughandtransportmaximumhasbeenreachedegglucosetransportindiabetics3TubularsecretionfromperitubularcapillariestubulesAlsobydiffusionandtranscellularmediatedtransportMostimportantsubstancessecretedHandKUsuallycoupledtoreabsorptionofNaAmountexcretedFilteredreabsorbedsecretedPAHallwillbeexcretedNaandH20filteredandalotreabsorbed99Glucoseall100reabsorbedUrea44reabsorbedK86reabsorbedbutalsosecretedCellsProteinsalbuminglobulinsProteinboundsubstances50ofCaionusuallybindtoalbuminfattyacidsDOESNTFiltratetoBowmanscapsuleTherearethree3physicalforcesthatestablishfiltrationratePGCglomerularcapillarybloodpressurepushingplasmaintoBowmansspacePBSfluidpressureinBowmanscapsulepullsfiltratebacktocapillaryGCosmoticforceduetoproteininplasmapullsfiltratebacktocapillaryNetglomerularfiltrationpressurePGCPBSGCGFRvolumeoffluidfilteredfromtheglomerulusintoBowmansspaceperunittime
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