PHGY 210 Lecture : PHGY210- Lecture 34- Dr. Takano.docx

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Glomerular filtration rate (gfr): the volume of fluid filtered from the glomeruli into bowman"s space per unit time. Normal gfr (70 kg person): 180 l/day (125 ml/min) N. b. plasma volume of this person: 3. 5 l. Plasma is filtered 51 times a day at glomeruli! membrane permeability surface area available for filtration. Filtered load: total amount of any freely filtered substance. Filtered load = gfr x plasma concentration of the substance e. g. filtered load of glucose = 180 l/day x 1 g/l = 180 g/day. Filtered load > amount excreted in the urine: net reabsorption. Filtered load < amount excreted in the urine: net secretion. Two mechanisms of reabsorption diffusion and mediated transport. Reabsorption by diffusion: often across the tight junctions connecting the tubular epithelial cells. E. g. urea reabsorption in the proximal tubule. ->urea concentration in the tubular fluid becomes higher. ->urea diffuses into the interstitial fluid and peritubular capillaries. Reabsorption by mediated transport occurs across tubular cells (transcellular epithelial transport).

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