PHGY 210 Lecture Notes - Trypsin Inhibitor, Amylase, Pancreatic Juice

57 views8 pages

Document Summary

Weak barrier (agents responsible: aspirin and nsaids, heliobacter pylori: normal barrier. Excessive hcl output (eg: gastrin producing factors) Also results in afferent fibres going up and efferent fibres as well. Gastrin is released in response to: secretagogues (products of protein digestion) (antrum lumen, local enteric reflexes, vagally-mediated reflexes. Physiological role of gastrin: hcl secretion, trophic effect. Histamine administration elicits large volume of gastric juice with lots of hcl. Histamine is constantly released and presented to the parietal cells as a tonic background, sensitizing them to other stimuli. Blocking this tonic background by h2-antagonists, inhibits acid secretion in response to ach and gastrin. (h+/k+ atpase, eg: nexium) H2 blockers are widely used to decrease hcl secretion (eg: pepsid). Optimal secretory activity is the result of an interplay between neural and hormonal mechanisms. Gastric secretion at any moment in time reflects a balance between stimulatory and inhibitory influences.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents