Class Notes (834,804)
Canada (508,727)
Physiology (903)
PHGY 210 (301)
Ann Wechsler (112)

PHGY210- Lecture 30- Dr. Wechsler.docx

8 Pages
Unlock Document

PHGY 210
Ann Wechsler

Lecture 29- Friday, March 19 , 2010h Ulcers 1. Normal HCl output  Weak barrier (agents responsible: Aspirin and NSAIDs, Heliobacter pylori) 2. Normal Barrier  Excessive HCl output (eg: Gastrin producing factors) Phases of Gastric Secretion:  Cephalic psychic, gustatory  Gastric  Intestinal Cephalic Phase (Vagally-mediated) -All regulatory cells are secreting. Accompanied by vasodilation. Distension leads to short intramural reflexes. Also results in afferent fibres going up and efferent fibres as well. Called vagal-vagal reflex. GASTRIN is released in response to: a) SECRETAGOGUES (products of protein digestion) (Antrum Lumen) b) Local enteric reflexes c) Vagally-mediated reflexes Physiological Role of Gastrin a) HCl secretion b) Trophic effect Histamine Lots of Histamine in gastric mucosa. Histamine administration elicits large volume of gastric juice with lots of HCl. PERMISSIVE HYPOTHESIS (Paracrine Fashion)– Histamine is constantly released and presented to the Parietal Cells as a tonic background, sensitizing them to other stimuli. Blocking this tonic background by H2-antagonists, inhibits acid secretion in response to ACh and Gastrin. (H+/K+ ATPase, eg: Nexium) H2 blockers are widely used to decrease HCl secretion (eg: Pepsid). Intestinal Phase Intestinal Phase – Inhibitory Optimal secretory activity is the result of an interplay between neural and hormonal mechanisms. Gastri
More Less

Related notes for PHGY 210

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.