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PHGY210- Lecture 38- Dr. Takano.docx

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PHGY 210
Ann Wechsler

PHYSIOLOGY 210 Class NotesRENAL5142012 42500 PM thLecture 37 Monday April 12 2010Classification of Acidosis and Alkalosis Low H concentration high pH alkalosis Respiratory alkalosis results from altered respirationMetabolic alkalosis results from other causes High H concentration low pH acidosis Respiratory acidosis results from altered respiration Metabolic acidosis results from other causesRenal Responses to Alkalosis and Acidosis Responses to acidosis high H concentration 1 Sufficient H are secreted to reabsorb all the filtered HCO 32 Still more H are secreted and this contributes new HCO to the plasma as 32these H are excreted bound to nonHCO buffer such as HPO 343 Tubular glutamine metabolism and ammonium excretion are enhanced which also contributes new HCO to the plasma 3Net result More new HCO than usual are added to the plasma thereby compensating for 3the acidosis The urine is highly acidic lowest attainable pH44 Responses to alkalosis low H concentration 1 Rate of H secretion is inadequate to reabsorb all the filtered HCO so the 3significant amounts of HCO are excreted in the urine 32 There is little or no H secretion on nonHCO urinary buffers33 Tubular glutamine metabolism and ammonium excretion are decreased so that little or no new HCO is contributed to the plasma from this source 3Net result Plasma HCO will decrease thereby compensating for the alkalosis The urine 3is highly alkaline pH74
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